Ketogenic diet treatment for pediatric super-refractory status epilepticus

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Ketogenic diet treatment for pediatric super-refractory status epilepticus

PURPOSE We aimed to study whether ketogenic diet (KD) therapy leads to resolution of super-refractory status epilepticus in pediatric patients without significant harm. METHOD A retrospective review was performed at Phoenix Children's Hospital on patients with super-refractory status epilepticus undergoing ketogenic diet therapy from 2011 to 2015. RESULTS Ten children with super-refractory ...

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Ketogenic Diet in Super-Refractory Status Epilepticus

Researchers from the Children's National Health System in Washington, D.C. studied the feasibility, rate of complications, and effect on seizures of initiating the Ketogenic Diet (KD) in pediatric patients with Super-Refractory Status Epilepticus (SRSE).

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Intravenous initiation and maintenance of ketogenic diet: Proof of concept in super-refractory status epilepticus

Super-refractory status epilepticus (SE) is characterized by unresponsiveness to initial anaesthetic therapy. This definition encompasses a SE that continues or recurs 24 h or more after the onset of anaesthetic therapy and includes those cases in which SE recurs on the reduction or withdrawal of anaesthesia. Treatment is difficult due to the failure of firstand second-line therapy. As no contr...

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Pediatric super-refractory status epilepticus treated with allopregnanolone.

Super-refractory status epilepticus is a life-threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic γ-aminobutyric acid (GABA)A receptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence. The neurosteroid allopregnanolone acts as a positive alloster...

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BRIEF COMMUNICATION Pediatric Super-Refractory Status Epilepticus Treated with Allopregnanolone

Super-refractory status epilepticus is a life-threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic c-aminobutyric acid (GABA)A receptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence. The neurosteroid allopregnanolone acts as a positive alloster...

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ژورنال

عنوان ژورنال: Seizure

سال: 2016

ISSN: 1059-1311

DOI: 10.1016/j.seizure.2016.07.006